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Choline Benefits

Choline benefits your liver, brain, and every cell in your body. It's critical for the processes that keep us alive. Learn more.

We shouldn’t call this article “choline benefits,” even though that’s what you’re searching for. We should call it “the necessity of choline” because that’s really a better way to think about it. Choline doesn’t have benefits per se; it performs essential functions that you need to survive. Choline constitutes a critical component of every cell in your body, and keeps your liver and brain communication network functioning. It should be no surprise that deficiency leads to mortal illness.

We can make a tiny amount of choline in our bodies, which is why it isn’t considered a vitamin, but that amount is nowhere near what we need to maintain the basic functions of our cells. The National Institutes of Health recommend 425 mg per day for adult women and 550 mg per day for adult men and pregnant women.

Per the NIH: “Most people in the United States consume less than the AI for choline. An analysis of data from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) found that the average daily choline intake from foods and beverages among children and teens is 256 mg for ages 2–19. In adults, the average daily choline intake from foods and beverages is 402 mg in men and 278 mg in women. Intakes from supplements contribute a very small amount to total choline intakes.”

Abject deficiency is rare, but as the NIH states, it is dangerous: “Choline deficiency can cause muscle damage, liver damage, and nonalcoholic fatty liver disease (NAFLD or hepatosteatosis)”. Most people are not putting themselves at great risk for these illnesses, but they are not getting enough to thrive. And with the tolerable upper limit declared at 3,500 mg/day, taking too much is pretty difficult.

Choline Benefits Every Cell in Your Body

Choline is necessary for the normal function of all cells. It’s what ensures the structural integrity and the signaling functions of the cell. It’s a precursor to phosphatidylcholine, which is the phospholipid that makes up the majority of the cell membrane, which protects the cell from its surroundings. And it’s found in sphingomyelin, which is another phospholipid membrane.

These two phospholipids are also precursors to cell-signaling molecules that facilitate communication between cells so they can all behave in a way that benefits the body as a whole.

Choline Benefits the Liver

Fats and cholesterol from your diet wind up in your liver where they are converted into very-low-density lipoproteins (VLDL) that transport via the bloodstream to tissues outside of the liver. Phosphatidylcholine plays a vital role in both assembling the VLDL and moving them from the liver to the bloodstream. Without phosphatidylcholine, fat and cholesterol build up in the liver and lead to non-alcoholic fatty liver disease and liver cell death. Fatty liver is a symptom of choline deficiency.

Choline Benefits the Brain

Choline plays a critical role in neurotransmission, the brain cell communication process. A small amount of dietary choline is converted to acetylcholine, which is a neurotransmitter that the nerves use to control breathing, heart rate, and skeletal muscles. “Because the rate of acetylcholine synthesis is most likely determined by choline availability (or, possibly, acetyl-CoA), dietary choline intake may directly affect cholinergic stimulation.”

The need for choline for optimal cognition starts in the womb. The placenta is sensitive to choline and recent studies show that higher maternal choline intake decreased multiple unfavorable conditions — including infant plasma cortisol — for the child that could be problematic later in life. Choline is also important right after birth, as authors of a 2011 literature review state, “High choline intake during the perinatal period has been demonstrated to have a lasting neuroprotective effect in both animal and human studies.”

Seven years after the study of maternal choline levels, the researchers followed up with the kids. “Results of the cognitive assessment revealed lasting benefits of the higher maternal choline intake on child attention, memory, and problem solving, providing the first randomized controlled trial evidence that higher maternal choline intake has benefits that last into the school-age years.”

A recent meta-analysis takes the benefits further into older adulthood when supplementation with choline improved memory and behavior in elderly people with chronic cerebral problems.

How to Get Choline Benefits

Choline is easy to get in diet with whole eggs as a great source. Some people have chosen to supplement with choline or its downstream version phosphatidylcholine. The liposomes in our Lypo-Spheric® supplements that encapsulate the nutrients contain 500 mg of phosphatidylcholine in each dose. A packet of most of the Lypo-Spheric® supplements contains 12% of your daily value of choline.

Tags: brain, Science